Chicken and Artichoke Casserole with Cheese is a comforting, oven-baked dish that blends tender chicken, tangy artichokes, and rich melted cheese into one satisfying meal. Inspired by Mediterranean flavors and classic home-style casseroles, this recipe delivers a creamy, savory experience that feels both hearty and elegant. The mild sweetness of baked chicken pairs beautifully with the slightly briny artichokes, while the cheese brings everything together with a golden, bubbly finish. This casserole is ideal for family dinners, potlucks, or make-ahead meals, offering warmth, flavor, and convenience in every bite.

Why I Love This Recipe

I love this recipe because it is both comforting and flavorful without being complicated. It uses simple, familiar ingredients yet tastes special enough for guests. The combination of creamy sauce, tender chicken, and cheesy topping creates a dish that feels indulgent while still being well balanced. It is also easy to prepare ahead of time, which makes it perfect for busy schedules.

Why This Is a Must-Try Dish

This is a must-try dish because it brings together classic flavors in a way that is reliable and crowd-pleasing. Even people who are unsure about artichokes often enjoy them in this casserole because they add depth without overpowering the dish. If you are looking for a baked chicken recipe that is comforting, versatile, and full of flavor, this casserole deserves a spot on your table.

Recipe Overview

Preparation Time: 20 minutes
Cooking Time: 35–40 minutes
Total Time: Approximately 1 hour
Servings: 6
Calories: Approximately 460 calories per serving
Course: Main Course
Cuisine: American with Mediterranean influence

Ingredients

• 2 lb boneless, skinless chicken breasts or thighs, cut into bite-sized pieces
• 1 can artichoke hearts, drained and roughly chopped
• 1 cup shredded mozzarella cheese
• 0.5 cup grated Parmesan cheese
• 1 cup sour cream or Greek yogurt
• 0.5 cup mayonnaise
• 2 cloves garlic, minced
• 1 teaspoon dried oregano
• 1 teaspoon dried basil
• 0.5 teaspoon salt
• 0.5 teaspoon black pepper
• 2 tablespoons olive oil
• Optional garnish: chopped parsley

Cooking Directions

Preheat the oven to 375°F (190°C).
Lightly grease a baking dish with olive oil.
In a large bowl, combine sour cream, mayonnaise, garlic, oregano, basil, salt, and pepper.
Add chicken and artichokes and mix until evenly coated.
Transfer the mixture to the prepared baking dish.
Top with mozzarella and Parmesan cheese.
Bake uncovered until the chicken is cooked through and the top is golden and bubbly.
Allow to rest briefly before serving.

Step-by-Step Preparation Method

Step 1: Preheat oven and prepare the baking dish.
Step 2: Cut chicken into evenly sized pieces for even cooking.
Step 3: Mix sour cream, mayonnaise, garlic, herbs, salt, and pepper in a bowl.
Step 4: Fold chicken and artichokes into the sauce mixture.
Step 5: Spread the mixture evenly in the baking dish.
Step 6: Sprinkle mozzarella and Parmesan evenly on top.
Step 7: Bake until cheese is melted and lightly browned and chicken is fully cooked.
Step 8: Let the casserole rest for a few minutes before serving.

How to Serve This Recipe

Serve Chicken and Artichoke Casserole with Cheese hot, straight from the oven. It pairs well with steamed rice, pasta, or crusty bread to soak up the creamy sauce. A fresh green salad or roasted vegetables make excellent side dishes for a complete meal.

Recipe Tips

Use evenly sized chicken pieces to ensure consistent cooking.
Drain artichokes well to prevent excess moisture.
Cover loosely with foil if the cheese browns too quickly.
Let the casserole rest before serving to help it set.

Variations

Add sautéed spinach or mushrooms for extra vegetables.
Use rotisserie chicken for a quicker version.
Replace mozzarella with provolone or Monterey Jack for a different flavor.
Add a pinch of red pepper flakes for gentle heat.
Use Greek yogurt instead of sour cream for a lighter option.

Freezing and Storage

Store leftovers in an airtight container in the refrigerator for up to 4 days.
Freeze the unbaked or baked casserole for up to 2 months.
Thaw overnight in the refrigerator before reheating.
Reheat covered in the oven until warmed through.

Special Equipment Needed

Baking dish
Large mixing bowl
Cutting board and knife
Measuring cups and spoons

Frequently Asked Questions

Can I use canned or frozen artichokes?
Yes, canned artichokes work best, but thawed frozen artichokes can also be used.

Can I prepare this casserole ahead of time?
Yes, it can be assembled a day in advance and refrigerated before baking.

How do I know the chicken is fully cooked?
The chicken should be opaque and reach a safe internal temperature.

Can I make this dish low-carb?
Yes, serve it on its own or with low-carb vegetables instead of pasta or rice.

Conclusion

Chicken and Artichoke Casserole with Cheese is a rich, comforting, and versatile dish that brings together creamy textures and savory flavors in one satisfying bake. Easy to prepare and loved by many, it is perfect for family dinners, meal prep, or sharing at gatherings. This casserole is proof that simple ingredients, when combined thoughtfully, can create a meal that feels both cozy and special.