Step 1: Make the Homemade Barbecue Glaze: In a small saucepan, combine ketchup, brown sugar, apple cider vinegar, soy sauce, Worcestershire sauce, smoked paprika, garlic powder, onion powder, and cayenne pepper. Simmer over medium-low heat for 5–7 minutes, stirring frequently, until slightly thickened. Remove from heat and let cool slightly.

Step 2: Prepare the Salmon: Preheat the grill to medium-high heat (or heat a grill pan on the stove). Pat salmon fillets dry with a paper towel and brush lightly with olive oil. Season lightly with salt and pepper.

Step 3: Grill the Salmon: Place salmon fillets on the grill, skin-side down if applicable. Grill for 4–5 minutes per side, depending on thickness, brushing generously with the barbecue glaze during the last 2 minutes on each side. Salmon is done when it flakes easily with a fork and has a caramelized glaze.