Prep the Shrimp: Pat shrimp dry with paper towels to remove excess moisture. This ensures the breading sticks properly.
Prepare the Breading Stations: Station 1: In a shallow dish, mix flour, paprika, garlic powder, onion powder, cayenne, salt, and pepper. Station 2: Beat the eggs in a separate bowl. Station 3: Place panko breadcrumbs in another shallow dish.
Coat the Shrimp: Dredge each shrimp in the flour mixture, shaking off excess. Dip in beaten eggs, then coat evenly with panko breadcrumbs.
Heat the Oil: In a deep skillet or frying pan, heat about 1–2 inches of vegetable oil over medium-high heat until it reaches 350°F (175°C).
Fry the Shrimp: Fry shrimp in batches to avoid overcrowding, about 2–3 minutes per side, until golden brown and crispy. Remove with a slotted spoon and drain on a paper towel-lined plate.
Serve: Serve immediately with lemon wedges and your favorite dipping sauces.