In a small saucepan, combine cranberries, sugar, orange juice, orange zest, and optional cinnamon. Cook over medium heat until cranberries burst and mixture thickens, about 8–10 minutes. Set aside to cool.
In a mixing bowl, combine ground turkey with garlic powder, onion powder, smoked paprika, salt, and black pepper. Form 8 small patties.
Heat olive oil or butter in a skillet over medium heat. Cook turkey patties 4–5 minutes per side, or until fully cooked and golden brown.
Lightly toast slider buns in a skillet or oven.
Assemble sliders by spreading cranberry relish on the bottom bun, adding the turkey patty, optional toppings, and covering with the top bun.
Serve immediately.